A case-control study of burning mouth syndrome and sleep dysfunction.
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Chainani-Wu N, Madden E, Silverman S Jr.
Source Department of Orofacial Sciences, School of Dentistry, University of California, San Francisco, CA, USA.
OBJECTIVE: The objective of this study was to evaluate whether sleep dysfunction is a risk factor for burning mouth syndrome (BMS).
STUDY DESIGN: An age- and sex-matched case-control study of patients with BMS and controls with various oral conditions was conducted. A numerical rating scale for oral discomfort and the sleep scale from the medical outcomes study were used for measurements, and statistical analyses included use of logistic regression models.
RESULTS: The odds ratios for lowest versus highest quartiles were sleep disturbance (OR = 9.7, P = .0095), sleep problems index (SLP)6 (OR = 7.5, P = .032), and SLP9 (OR = 27, P = .0058), which remained significant after controlling for age and number of sedating medications.
CONCLUSIONS: Findings from this cross-sectional study, although unable to establish a causal relationship, demonstrate that patients with BMS report a greater degree of sleep problems as compared with controls, and suggest that sleep dysfunction may be a risk factor for BMS and a possible target for treatment.
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