Oral Lichen Planus

Oral Lichen Planus

Phytomedicine. 2007 Aug;14(7-8):437-46. Epub 2007 Jul 2. A randomized, placebo-controlled, double-blind clinical trial of curcuminoids in oral lichen planus. Chainani-Wu N, Silverman S Jr, Reingold A, Bostrom A, Mc Culloch C, Lozada-Nur F, Weintraub J. Source Department of Orofacial Sciences, School of Dentistry, University of California, San Francisco, CA 94143-0658, USA. nita.wu@ucsf.edu Abstract We studied the efficacy of curcuminoids in the treatment of oral lichen planus (OLP), a chronic, mucocutaneous, immunological disease. Curcuminoids are components of turmeric (Curcuma longa) that have anti-inflammatory activity. Turmeric has been used in Ayurveda (Indian traditional medicine) for centuries. A randomized, double-blind, placebo-controlled trial was conducted. In all, 100 consecutive, eligible patients with […]

Assessment of the use of sialogogues

Spec Care Dentist. 2006 Jul-Aug;26(4):164-70. Assessment of the use of sialogogues in the clinical management of patients with xerostomia. Chainani-Wu N, Gorsky M, Mayer P, Bostrom A, Epstein JB, Silverman S Jr. Source Department of Orofacial Sciences, University of California, San Francisco, Calif, USA. nitacwu@itsa.ucsf.edu Abstract This study was conducted to assess the clinical efficacy and adverse effects of pilocarpine, bethanechol and cevimeline in patients with xerostomia. In this open-label crossover assessment in 20 patients with xerostomia, a one- to two-week course of each medication with a one-week washout period was prescribed. Side effects, symptoms, whole stimulated and unstimulated saliva were measured. Each sialogogue was found to […]

Hepatitis C virus and lichen planus: a review.

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004 Aug;98(2):171-83. Hepatitis C virus and lichen planus: a review. Chainani-Wu N, Lozada-Nur F, Terrault N. Source Department of Stomatology, Division of Oral Medicine, Oral Pathology, and Oral Radiology, University of California, San Francisco, CA 94143-0658, USA. nitacwu@itsa.ucsf.edu Abstract INTRODUCTION: The relationship between hepatitis C virus (HCV) infection and oral lichen planus (OLP) remains a matter of controversy. It is important to determine whether there is an association between OLP and HCV infection so that guidelines regarding the routine HCV testing of patients with OLP can be developed for clinicians. OBJECTIVES: The objective of this […]

Comprehensive Lifestyle Changes on Telomerase

Lancet Oncol. 2013 Oct;14(11):1112-20. doi: 10.1016/S1470-2045(13)70366-8. Epub 2013 Sep 17. Effect of comprehensive lifestyle changes on telomerase activity and telomere length in men with biopsy-proven low-risk prostate cancer: 5-year follow-up of a descriptive pilot study. Ornish D, Lin J, Chan JM, Epel E, Kemp C, Weidner G, Marlin R, Frenda SJ, Magbanua MJ, Daubenmier J, Estay I, Hills NK, Chainani-Wu N, Carroll PR, Blackburn EH. Source Department of Medicine, University of California San Francisco, San Francisco, CA, USA; Preventive Medicine Research Institute, Sausalito, CA, USA. Electronic address: dean.ornish@pmri.org. Abstract BACKGROUND: Telomere shortness in human beings is a prognostic marker of ageing, disease, and premature morbidity. We previously found an association between 3 months of comprehensive lifestyle […]

Leukoplakia

Oral Dis. 2000 Jul;6(4):234-40. Integrin expression in oral hairy leukoplakia and normal tongue epithelium. Chainani-Wu N, Lagenaur LA, Peñaranda ME, Palefsky JM. Source Department of Stomatology, University of California, San Francisco, San Francisco, CA 94143, USA. Abstract OBJECTIVE: To describe the expression of integrins in the epithelium of oral hairy leukoplakia (HL) and compare to that of normal lateral tongue epithelium. MATERIALS AND METHODS: Immunohistochemistry to identify integrins (alpha 2, alpha 3, alpha 5, alpha 6, alpha v, beta 1) was performed, using a standard biotin-streptavidin-peroxidase technique on five clinically and histologically confirmed frozen biopsy specimens of HL and five normal lateral tongue control tissues. […]

Oral Lichen Planus

J Am Dent Assoc. 2001 Jul;132(7):901-9. Oral lichen planus: patient profile, disease progression and treatment responses. Chainani-Wu N, Silverman S Jr, Lozada-Nur F, Mayer P, Watson JJ. Source Department of Stomatology, School of Dentistry, University of California, San Francisco, USA. Abstract BACKGROUND: Oral lichen planus, or OLP, is a common mucocutaneous immunological disease. The objective of this study was to describe the patient profile, disease progression and treatment responses. METHODS: The authors conducted a retrospective, descriptive study using information from patient records at a tertiary referral center. The study included 229 patients with OLP who were seen in the oral medicine clinic at the University of […]

Safety and anti-inflammatory activity of curcumin

J Altern Complement Med. 2003 Feb;9(1):161-8. Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa). Chainani-Wu N. Source Department of Stomatology, University of California, San Francisco, CA 94143-0658, USA. nitacwu@itsa.ucsf.edu Abstract INTRODUCTION: Tumeric is a spice that comes from the root Curcuma longa, a member of the ginger family, Zingaberaceae. In Ayurveda (Indian traditional medicine), tumeric has been used for its medicinal properties for various indications and through different routes of administration, including topically, orally, and by inhalation. Curcuminoids are components of tumeric, which include mainly curcumin (diferuloyl methane), demethoxycurcumin, and bisdemethoxycurcmin. OBJECTIVES: The goal of this systematic review […]

Diet and oral, pharyngeal, and esophageal cancer

Nutr Cancer. 2002;44(2):104-26. Diet and oral, pharyngeal, and esophageal cancer. Chainani-Wu N. Source Department of Stomatology (Oral Medicine), University of California, San Francisco, CA 94143, USA. nitacwu@itsa.ucsf.edu Abstract Cancers of the upper digestive tract, including those arising in the oral cavity, pharynx, and esophagus, present a significant public health problem worldwide. These cancers are associated with high morbidity and mortality, and identification of protective factors is very important. A number of epidemiological studies have examined the association between vegetables, fruits, carotene, vitamin A, vitamin C, and vitamin E and oral, pharyngeal, and esophageal cancers. The results of 35 epidemiological studies, including one […]

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