Photomed Laser Surg. 2013 Apr;31(4):183-7. doi: 10.1089/pho.2012.3414. Epub 2013 Mar 8. A case report of conservative management of extensive proliferative verrucous leukoplakia using a carbon dioxide laser. Chainani-Wu N, Purnell DM, Silverman S Jr. Source Department of Orofacial Sciences, School of Dentistry, University of California, San Francisco, CA, USA. nita.wu@ucsf.edu Abstract OBJECTIVE: The purpose of this report was to describe a clinical case of conservative management of extensive proliferative verrucous leukoplakia (PVL) using a carbon dioxide laser, as an alternative to complete glossectomy, which led to a sustained successful outcome over a 12-year follow-up period. BACKGROUND DATA: Patients with oral PVL, a high […]

J Am Acad Dermatol. 2013 Jan;68(1):83-92. doi: 10.1016/j.jaad.2012.04.009. Epub 2012 May 8. Epidermolysis Bullosa Oropharyngeal Severity (EBOS) score: a multicenter development and reliability assessment. Fortuna G, Chainani-Wu N, Lozada-Nur F, Aria M, Cepeda-Valdes R, Pollio A, Marinkovich MP, Martinez-Salazar AE, Mignogna MD, Bruckner AL,Salas-Alanís JC. Source Department of Dermatology, Stanford University School of Medicine, Center for Clinical Sciences Research, Stanford, California 94305, USA. giulio.fortuna@gmail.com Abstract BACKGROUND: Epidermolysis bullosa (EB) is a genetic mucocutaneous disorder characterized by blister formation upon mild trauma. All 4 EB types may show oropharyngeal lesions involving either hard or soft tissues. Currently, there are very few data on EB scoring that include the oropharyngeal cavity. OBJECTIVES: […]

Phytomedicine. 2012 Mar 15;19(5):418-23. doi: 10.1016/j.phymed.2011.11.005. Epub 2012 Feb 2. Use of curcuminoids in a cohort of patients with oral lichen planus, an autoimmune disease. Chainani-Wu N, Collins K, Silverman S Jr. Source Department of Orofacial Sciences, School of Dentistry, 521 Parnassus Ave, C646, Box 0658, University of California, San Francisco, CA 94143-0658, USA. nita.wu@ucsf.edu Abstract OBJECTIVES: To summarize long-term open-label use of curcuminoids and experience of side-effects in 53 patients with the autoimmune condition oral lichen planus (OLP) who had previously participated in randomized controlled trials (RCTs) of curcuminoids at UCSF. METHODS: This descriptive retrospective cohort study conducted in 2009 collected information […]

J Am Acad Dermatol. 2012 May;66(5):752-60. doi: 10.1016/j.jaad.2011.04.022. Epub 2011 Sep 9. High-dose curcuminoids are efficacious in the reduction in symptoms and signs of oral lichen planus. Chainani-Wu N, Madden E, Lozada-Nur F, Silverman S Jr. Source Department of Orofacial Sciences, School of Dentistry, University of California, San Francisco, California 94143-0658, USA. nita.wu@ucsf.edu Abstract BACKGROUND: Curcuminoids are components of turmeric (Curcuma longa) that possess anti-inflammatory properties. OBJECTIVE: We sought to study the efficacy of curcuminoids in controlling the signs and symptoms of oral lichen planus, at doses of 6000 mg/d (3 divided doses), and their safety at this dose. METHODS: Twenty consecutive, eligible patients […]